Patents
 

Electronic time-temperature indicator (Patent 6,950,028)  (text)

Electronic time-temperature indicator and logger (Patent 7,102,526), (PCT/US2004/012491 pending)  (text)

This invention covers electronic time-temperature indicators with any type of output (visual, RFID, etc.), and other devices and methods by which the thermal history of a material may be monitored, and the subsequent fitness for use of the tracked material may be quickly ascertained. In particular, the invention discloses a rapidly reprogrammable electronic time-temperature tag that may be easily customized with the thermal time-temperature stability profile of an arbitrary material, using electronic data transfer methods. Using this device, a single, low-cost, generic time-temperature tag may be mass-produced, and then subsequently programmed to mimic the stability characteristics of nearly any material of interest.

PCT/US2004/012491 has been allowed in the US, and is pending in the national phase of most major markets worldwide.

Material lifetime data abstraction device and method (Patent 7,564,364) (text)

This invention covers improved electronic time-temperature indicators with an RFID output, and other devices and methods by which the thermal history of a complex material, which may not obey a simple exponential Arrhenius law degradation equation, may be monitored, and the subsequent fitness for use of the tracked material may be quickly ascertained. In particular, the invention discloses a rapidly reprogrammable electronic time-temperature RFID tag that may be easily customized with the thermal time-temperature stability profile of an arbitrary material, using electronic data transfer methods. Using this device, a single, low-cost, generic time-temperature tag may be mass-produced, and then subsequently programmed to mimic the stability characteristics of nearly any material of interest. By utilizing data compression to compress a material's extensive thermal history into the small user data field transmitted by modern RFID tags, a considerable amount of information relating to product status and cause of failure may be rapidly transmitted within the small memory confines of standard RFID tag protocols.

Method and device to detect therapeutic protein immunogenicity (Patent 8,190,374) 

The present invention consists of a time-temperature indicator device that has at least one parameter set to warn when a therapeutic protein drug has had a thermal history associated with increased risk of unwanted immunological activity. The indicator device is designed to remain with the drug as the drug travels throughout different links of the cold chain. In a preferred embodiment, the indicator device remains associated with the therapeutic protein from the time of manufacture up until the final few minutes before the drug is used. In alternate forms of the invention, additional parameters, including motion, light, and turbidity may also be monitored. Novel methods for determining therapeutic protein time-temperature immunological risk parameters, and programming or adjusting the indicator device, are also disclosed.

 

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